The MTSS Center partnered with the Wyoming Department of Education to create the Wyoming MTSS Center. The Wyoming MTSS Center was a multi-year effort to support Wyoming educators with implementation. Center staff provided intensive training to school-level teams, targeted workshops on key topics, and universal webinars on introductory MTSS. Staff also developed a website, created unique resources, and engaged in an active marketing campaign. Schools that worked with the Wyoming MTSS Center experienced a near moderate increase in implementation (effective size of d = 0.40).