This brief developed by the Center on Great Teachers & Leaders outlines a framework for coherence that supports states in connecting college and career readiness standards, multi-tiered systems of support (MTSS), and educator effectiveness by capitalizing on their shared goal: improving instructional quality to enhance educational outcomes for students. The brief asks readers to examine the shared goals, context, and identify instructional connections across initiatives that support better learning outcomes for all students. Additionally, readers can explore opportunities to enhance the alignment and conceptual coherence of these initiatives in an effort to improve student outcomes.